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Update on Safety of Biologics


Release Date:January 4, 2013
Estimated Time of Completion: 15 minutes


The Rheumatology Highlights Report Series is designed for the busy clinician. It provides highlights from key scientific presentations and/or abstracts presented at the national rheumatology meeting. Clinical experts attending this meeting have selected the most significant data to report. Each activity is a 15-minute presentation. Enhancements include downloadable audio, slide sets, and list of related abstracts. This report reviews the biologic effects on vaccine response and efficacy, as well as the current recommendations for tuberculosis (TB), shingles, and rheumatoid arthritis testing and treatment.

Learning Objectives

  1. Describe screening recommendations and safety issues for tofacitinib.
  2. Review current research data on herpes zoster vaccines.
  3. Cite when repeat TB testing might be indicated as well as management of antirheumatic medications during TB treatment.
  4. Describe the effect that various biologics have on vaccine response and efficacy.

Target Audience

This activity is directed to rheumatologists, immunologists, clinical researchers, and allied health professionals, including nurse practitioners and physician assistants.

Activity Director and Faculty

Activity Director

Leonard H. Calabrese, DO
Professor of Medicine
RJ Fasenmyer Chair of Clinical Immunology
Vice Chairman, Department of Rheumatic and Immunologic Diseases
Cleveland Clinic Lerner College of Medicine
Cleveland, Ohio


The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician or other health care provider relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this educational activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation or Peking Union Medical College Hospital be liable for any decision made or action taken in reliance upon the information provided through this educational activity.


In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty has indicated that he may have a relationship which, in the context of his presentation, could be perceived as a potential conflict of interest:

Leonard H. Calabrese, DO

Amgen Inc.


Centocor, Inc.



Sanofi Aventis


Consulting, Teaching & Speaking


Consulting/Teaching and Speaking

Consulting/Teaching and Speaking

Consulting/Teaching and Speaking

Consulting, Data Safety Monitoring Board


Begin Activity in English

This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education and Digestive Disease Institute.

How to Obtain Your Certificate of Participation

  1. Participate in the activity.
  2. Login to your account.
  3. Complete the evaluation.
  4. Print your certificate.