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Case-Based Lessons from the Cleveland Clinic Department of Rheumatologic and Immunologic Disease:
An emerging autoinflammatory disease

NOD2-associated autoinflammatory disease

Release Date:   Oct 10, 2014

Estimated Time of Completion:  15 minutes


This is an interactive case-based lesson from the Cleveland Clinic Department of Rheumatologic and Immunologic Disease . Read each section of the case and answer the questions. You may proceed to the next section once you answer each question correctly. In addition to allowing you to proceed, the correct answer also reveals the rationale, with references when appropriate. Upon completing the CME activity and the evaluation and registration forms, you will have an opportunity to print your CME certificate for your records.


The purpose is to introduce an emerging autoinflammatory disease..

Learning Objectives

At the conclusion of this activity, the participant will be able to:

  1. Recognize NOD2-associated autoinflammatory disease

  2. Review the differential diagnosis of the whole spectrum of autoinflammatory diseases

  3. Describe current concepts of autoinflammatory diseases as derived from recent publications about the disease

Target Audience

This activity is directed to: rheumatologists, general internists, dermatologists, gastroenterologists

Activity Director

Activity Director

Qingping Yao, MD, PhD
Department of Rheumatic and Immunologic Diseases,
Cleveland Clinic, Cleveland, OH


The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician or other health care provider relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this educational activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation or Peking Union Medical College Hospital be liable for any decision made or action taken in reliance upon the information provided through this educational activity.


Begin Activity in English

How to Obtain Your Certificate of Participation

  1. Participate in the activity.
  2. Login to your account.
  3. Complete the evaluation.
  4. Print your certificate.